Blar i forfatter "Le Couteur, David G"

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    • The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell 

      Hunt, Nicholas J; Lockwood, Glen P; Kang, Sun; Pulpitel, Tamara; Clark, Ximonie; Mao, Hong; McCourt, Peter Anthony; Cooney, Greg; Wali, Jibran; Le Couteur, Frank; Le Couteur, David G; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-14)
      Age-related changes in the liver sinusoidal endothelium, particularly the reduction in fenestrations, contribute to insulin resistance in old age. Metformin impacts on the aging process and improves insulin resistance. Therefore, the effects of metformin on the liver sinusoidal endothelium were studied. Metformin increased fenestrations in liver sinusoidal endothelial cells isolated from both young ...

    • Opportunities and Challenges for Nanotherapeutics for the Aging Population 

      Hunt, Nicholas J; McCourt, Peter Anthony; Kuncic, Zdenka; Le Couteur, David G; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-25)
      Nanotherapeutics utilize the properties of nanomaterials to alter the pharmacology of the drugs and therapies being transported, leading to changes in their biological disposition (absorption, distribution, cellular uptake, metabolism and elimination) and ultimately, their pharmacological effect. This provides an opportunity to optimize the pharmacology of drugs, particularly for those that are ...

    • Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice 

      Hunt, Nick; Lockwood, Glen P; Kang, Sun Woo; Westwood, Lara; Limantoro, Christina; Chrzanowski, Wojciech; McCourt, Peter Anthony; Kuncic, Zdenka; Le Couteur, David G; Cogger, V.C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-24)
      Orally administered Ag<sub>2</sub>S quantum dots (QDs) rapidly cross the small intestine and are taken up by the liver. Metformin and nicotinamide mononucleotide (NMN) target metabolic and aging processes within the liver. This study examined the pharmacology and toxicology of QD-based nanomedicines as carriers of metformin and NMN in young and old mice, determining if their therapeutic potency and ...

    • Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots. 

      Hunt, Nicholas J; Lockwood, Glen P; Le Couteur, Frank H.; McCourt, Peter Anthony; Singla, Nidhi; Kang, Sun; Burgess, Andrew; Kuncic, Zdenka; Le Couteur, David G; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-24)
      Quantum dots (QDs) are used for imaging and transport of therapeutics. Here we demonstrate rapid absorption across the small intestine and targeted delivery of QDs with bound materials to the liver sinusoidal endothelial cells (LSECs) or hepatocytes in vitro and in vivo following oral administration. QDs were radiolabeled with <sup>3</sup> H-oleic acid, with a fluorescent tag or <sup>14</su ...

    • The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells 

      Svistounov, Dmitri; Warren, Alessandra; McNerney, Gregory P; Owen, Dylan M.; Zencak, Dusan; Zykova, Svetlana N; Crane, Harry; Huser, Thomas; Quinn, Ronald J.; Smedsrød, Bård; Le Couteur, David G; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Fenestrations are transcellular pores in endothelial cells that facilitate transfer of substrates between blood and the extravascular compartment. In order to understand the regulation and formation of fenestrations, the relationship between membrane rafts and fenestrations was investigated in liver sinusoidal endothelial cells where fenestrations are grouped into sieve plates. Three dimensional ...